Synonyms: DBCO PEG Carbonylacrylic acid, Carbonylacrylic acid PEG5k DBCO, Carbonylacrylic PEG DBCO

Product Description:

Carbonylacrylic PEG DBCO is one of Nanocs' thiol reactive PEG derivatives that have a terminal DBCO group which can go Copper free Click Chemistry. Similar to Maleimide, carbonylacrylic group reacts with thiol group quickly to form a stable thiol ether bond via so called ene-thiol Michael addition. Unlike maleimide-thiol adduct, the reaction between carbonylacrylic acid and thiol is non-reversible, and therefore the adduct is more stable for carbonylacrylic acid thiol conjugate. Carbonylacrylic acid reagents have been excellent reagents for site-specific Cysteine modification. DBCO, on the other hand, can react to azide group via Click Chemistry without need copper catalyst. 

Product Specifications:

• Form: Solid
• Apearance: Light yellow
• Reactive groups: Carbonylacrylic and DBCO
• Reactive to: Sulfhydryl and azide groups
• Solubility: Soluble in water

Storage:

• Store at -20 ⁰C. Desiccate.