Synonyms: Carboxylic acid PEG Carbonylacrylic, Carbonylacrylic PEG acid

Description:

Carbonylacrylic PEG Acid is one of Nanocs' thiol reactive PEG derivatives that have a terminal carboxylic group which can react with amine or hydroxyl groups. Similar to Maleimide, carbonylacrylic group reacts with thiol group quickly to form a stable thiol ether bond via so called ene-thiol Michael addition. Unlike maleimide-thiol adduct, which can hydrolyze at alkaline pH, the reaction between carbonylacrylic acid and thiol is non-reversible, and therefore the adduct is more stable for carbonylacrylic acid thiol conjuate. Carbonylacrylic acid reagents have been excellent reagents for site-specific Cysteine modification. Carboxylic group, on the other hand, can be activated to react with either amine or hydroxyl groups.

Product Specifications:

• Form: Solid
• Apearance: Yellow/pink
• Reactive groups: Carbonylacrylic and COOH
• Reactive to: Sulfhydryl and primary amine/hydroxyl groups
• Solubility: Soluble in water

Storage:

• Store at -20 ⁰C. Desiccate.