Carbonylacrylic PEG COOH
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Synonyms: Carboxylic acid PEG Carbonylacrylic, Carbonylacrylic PEG acid
Description:
Carbonylacrylic PEG Acid is one of Nanocs' thiol reactive PEG derivatives that have a terminal carboxylic group which can react with amine or hydroxyl groups. Similar to Maleimide, carbonylacrylic group reacts with thiol group quickly to form a stable thiol ether bond via so called ene-thiol Michael addition. Unlike maleimide-thiol adduct, which can hydrolyze at alkaline pH, the reaction between carbonylacrylic acid and thiol is non-reversible, and therefore the adduct is more stable for carbonylacrylic acid thiol conjuate. Carbonylacrylic acid reagents have been excellent reagents for site-specific Cysteine modification. Carboxylic group, on the other hand, can be activated to react with either amine or hydroxyl groups.
Product Specifications:
- Form: Solid
- Apearance: Yellow/pink
- Reactive groups: Carbonylacrylic and COOH
- Reactive to: Sulfhydryl and primary amine/hydroxyl groups
- Solubility: Soluble in water
Storage:
- Store at -20 0C. Desiccate.