DSPE-PEG-NHS, MW 3400

Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

• Form: Solid;
• Color: White;
• Solubility: Soluble in chloroform, warm water;
• Reactive group: Succinimidyl NHS Ester;
• Reactive to: Primary amine group (-NH2);
• Lipid type: C18, saturated;
• Purity: >90%;

Storage Conditions:

• Store at -20 ⁰C. Avoid frequent thaw and freeze.